Eddie was a graduate student in the lab. He was in the Pharmacology Graduate Group. Eddie graduated from Colby College in 2014 with a BA in biochemistry and mathematics. He is from Boston and a Celtics and Patriots fan. Eddie's hobbies include skiing, rock climbing, and ultimate frisbee. He is super excited to try out all the local food and craft beers in Philly. In 2018, Eddie won a Blavatnik Family Fellowship in Biomedical Research. In 2019, Eddie won the John S. O'Brien Award for best oral presentation at the annual PGG Retreat. Eddie defended his Ph.D. thesis 'Pharmacological stimulation of the human Hsp70 protein-disaggregase system' in August 2020. Eddie went on to pursue a post-doc with Monica Driscoll at Rutgers University.
Publications
Lin, J., P.J. Carman, C.W. Gambogi, N.M. Kendsersky, E. Chuang, S.N. Gates, A.L. Yokom, A.N. Rizo, D.R. Southworth, and J. Shorter. (2024). Design principles to tailor Hsp104 therapeutics. bioRxiv. doi:10.1101/2024.04.26.591398. pdf file link
Chuang, E., R.R. Cupo, J.R. Bevan, M.L. Rice, S. Mao, E.L. Gorenberg, K.L. Mack, D.M. Huryn, P. Wipf, J.L. Brodsky, and J. Shorter. (2024). Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins. bioRxiv. doi: 10.1101/2024.01.11.575109. pdf file link
Mack, K.L.*, H. Kim*, E.M. Barbieri, J. Lin, S. Braganza, M.E. Jackrel, J.E. DeNizio, X. Yan, E. Chuang, A. Tariq, R.R. Cupo, L.M. Castellano, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2023). Tuning Hsp104 specificity to selectively detoxify α-synuclein. Mol. Cell. 83(18):3314-3332.e9. pdf file link (*Co-first author.).
Cupo, R.R.*, A. Rizo*, G.A. Braun, E. Tse, E. Chuang, K. Gupta, D.R. Southworth, and J. Shorter. (2022). Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Rep. 40(13): 111408. pdf file link (*Co-first author).
March, Z.M., K. Sweeney°, H. Kim°, X. Yan°, L.M. Castellano, M.E. Jackrel, J. Lin, E. Chuang, E. Gomes, C. W. Willicott, K. Michalska, R. Jedrzejczak, A. Joachimiak, K.A. Caldwell, G.A. Caldwell, O. Shalem, and J. Shorter. (2020). Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife. 9:e57457. pdf file link (°Co-second author).
Jones, R.D., C. Enam, R. Ibarra, H.R. Borror, K.E. Mostoller, E.K. Fredrickson, J. Lin, E. Chuang, Z. March, J. Shorter, T. Ravid, G. Kleiger, and R.G. Gardner. (2020). The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Mol. Biol. Cell. 31(3):221-233. pdf file link
Michalska, K.*, K. Zhang*, Z.M. March*, C. Hatzos-Skintges, G. Pintilie, L. Bigelow, L.M. Castellano, L.J. Miles, M.E. Jackrel, E. Chuang, R. Jedrzejczak, J. Shorter, W. Chiu, and A. Joachimiak. (2019). Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events. Structure. 27(3):4490463. pdf file link (*Co-first author).
Chuang, E.*, A.M. Hori*, C.D. Hesketh*, and J. Shorter. (2018). Amyloid assembly and disassembly. J. Cell. Sci. doi: 10.1242/jcs.189928. pdf file link (*Co-first author).
Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. pdf file link (*Co-first author).
Torrente, M.P., E. Chuang, M.M. Noll, M.E. Jackrel, M.S. Go, and J. Shorter. (2016). Mechanistic insights into Hsp104 potentiation. J. Biol. Chem. 291(10):5101-5115. pdf file link
Millard, J.T., E. Chuang, J.S. Lucas, E.E. Nagy, and G.T. Davis. (2013). Case-Study Investigation of Equine Maternity via PCR-RFLP: A Biochemistry Laboratory Experiment. J Chem Educ. 90(11). doi: 10.1021/ed300740r. pdf file link
